Chen Research Group

•  Chen, Q.*; Schneller, S. W.; Liu, C.; Jones, K. L.; Singer, T. 5'-Nor-3-Deaza-1',6'-Isoneplanocin, the synthesis and antiviral study.  Molecules.  2020, 25, 3865. DOI: 10.3390/molecules25173865.

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• Liu, C.; Chen, Q.; Scheller, S. W. Synthesis of D-like and L-like 5’-fluoro-5’-deoxy-1’6’-isoneplanocins and their antiviral activity including Ebola. Nucleosides Nucleotides and Nucleic Acids, 2020, 39, 342-348 (invited paper).

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• Chen, Q.*; Smith, A.; L-like 3-deazaneplanocin analogues: synthesis and antiviral properties. Bioorganic & Medicinal Chemistry Letters. 2019, 29, 126613. ​

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• Liu, C.; Coleman, R.; Archer, A.; Hussein, I.; Bowlin, T.; Chen, Q.; Schneller, S. W. Enantiomeric 4’-Truncated 3-deaza-1’,6’-isoneplanocins: synthesis and antiviral properties including Ebola. Bioorganic & Medicinal Chemistry Letters. 2019, 29, 2480-2482.

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• Liu, C.; Chen, Q.; Steven Cardinalec; Bowlin, T. L.; Schneller, S. W. 6’-Fluoro-3-deazaneplanocin: synthesis and antiviral properties, including Ebola. Bioorganic & Medicinal Chemistry Letters. 2018, 28, 3674-3675.

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• Chen, Q.; Liu, C.; Bowlin, T. L.; Schneller, S. W. 5’-Hydroxy-5’-homoaristeromycin: Synthesis and antiviral properties. Bioorganic & Medicinal Chemistry Letters. 2018, 28, 1456-1458.

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• Chen, Q.*; Davidson, A. Synthesis, Conformational Study and Antiviral Activity of L-like Neplanocin Derivatives. Bioorganic & Medicinal Chemistry Letters. 2017, 27, 4436-4439.

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• Liu, C.; Chen, Q.; Schneller, S. W. Both enantiomers of the isomer of neplanocin A possessing the 4'-hydroxylmethylene substituent at the 6'-position. Nucleosides Nucleotides and Nucleic Acids, 2017, 36, 631-636.

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• Yin, X.; Chen, Q.; Ye, W.; Liu, C.; Schneller, S. W. 8-Methyl Derivatives of Aristeromycin, Neplanocin, 3-Deazaneplanocin and Related Analogs Heterocycles, 2017. 95, 445-461. (Invited paper)

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• Liu, C.; Chen, Q.; Schneller, S. W. Enantiomeric 3-deaza-1’, 6’-isoneplanocin and its 3-bromo analogue: Synthesis by the Ullmann reaction and their antiviral properties. Bioorganic & Medicinal Chemistry Letters, 2016, 26, 928-930.

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• Liu, C.; Chen, Q.; Gorden, J. D.; Schneller, S. W. 2- and 3-Fluoro-3-deazaneplanocins, 2-fluoro-3-deazaaristeromycins, and 3-methyl-3-deazaneplanocin: Synthesis and antiviral properties. Bioorganic & Medicinal Chemistry, 2015, 23, 5496-5501.

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• Chen, Q.; Schneller, S. W. Synthesis, antiviral activity and enzymatic inhibitory mechanism of 3-deaza-3-fluoro carbocyclic nucleosides. Bioorganic & Medicinal Chemistry, 2014, 22, 6961-6964.

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• Chen, Q.; Liu, C.; Schneller, S. W., Metathesis reaction for side chain construction in carbocyclic sinefungin analogues synthesis, Tetrahedron, 2014, 70, 892-900. NIHMS: 552858

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• Liu, C.; Chen, Q.; Yang, M; Schneller, S. W. C-3 Halo and 3-methyl substituted 5'-nor-3-deazaaristeromycins:  synthesis and antiviral properties. Bioorganic & Medicinal Chemistry, 2013, 21, 359-364

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• Liu, C.; Chen, Q.; Schneller, S. W. 3-Bromo-3-deazaneplanocin and 3-bromo-3-deazaaristeromycin: synthesis and antiviral activity, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 5182-5184

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• Liu, C.; Chen, Q.; Schneller, S. W. (+)-Neplanocin F, 2'-fluoroneplanocin, and a 6’-isoneplanocin via a common versatile cyclopentenol precursor, Tetrahedron Letters. 2011, 52, 4931.